Indeed, the Marvel Universe is home to a plethora of unique and powerful weapons and artifacts. The ones you mentioned are indeed some of the most notable and formidable in Marvel lore. Let’s briefly go over each one:

8. The Ultimate Nullifier: A small device with immense power, capable of erasing targets from existence or destroying entire planets. It was famously used by Johnny Storm of the Fantastic Four to stop Galactus.

7. Infinity Gauntlet: This iconic weapon, along with the Infinity Stones, grants its wielder god-like powers, enabling them to reshape reality, control time, manipulate minds, and more. Thanos famously used it to devastating effect.

6. The Black Vortex: An artifact that grants individuals the ability to amplify their powers and potential to incredible levels. However, the power of the Black Vortex can be corrupting and lead users down a dark path.

5. The Crimson Gem of Cyttorak: A mystical gem that grants its bearer incredible strength, speed, endurance, and the ability to manipulate magnetic fields, magic, and even achieve a degree of immortality.

4. The Evil Eye of Avalon: Also known as the Evil Eye, this mystical treasure allows the user to manipulate matter, master spacetime, and unleash powerful bursts of energy. It has been the cause of conflicts between powerful entities.

3. The Darkhold: A forbidden book of dark magic that grants its readers vast and dark magical knowledge. It has been linked to the creation of vampires and other dark events, and its power can have detrimental effects on those who read it.

2. The M’kraan Crystal: A giant pink crystal that holds a neutron galaxy and is known as “The End of All Things.” Its destruction would lead to the annihilation of the universe, making it a highly significant and dangerous artifact.

1. The Heart of the Universe: The most powerful item in the Marvel Universe, second only to The One Above All. Possessing the Heart of the Universe grants ultimate power, allowing the wielder to manipulate all aspects of existence. Thanos famously wielded this power and caused tremendous destruction.

These weapons and artifacts play significant roles in various Marvel storylines and often have immense consequences for the characters and the universe itself. Their power levels and abilities make them formidable and sought-after by heroes and villains alike.